Using commercial infant formula or pasteurized breast milk to feed the baby in order to avoid exposing them to CMV through their mother’s milk.Ībout 40-50% of babies with abnormal TREC results are confirmed through follow-up testing to have a T cell deficiency.

Avoiding live vaccines, such as the rotavirus (oral) vaccine, and using blood that is depleted of white blood cells (or irradiated) and does not contain any cytomegalovirus (CMV) if the infant requires a blood transfusion.

Starting immunoglobulin (Ig) replacement therapy and/or prophylactic antibiotics, antiviral, and antifungal medications.

Isolating the baby to protect the infant from developing infections.

The family should follow the provider’s directions about what to do next, which may include: Low or no T cells means the baby’s immune system is not functioning properly.

T cells are vital components of the immune system that prevent life-threatening infections. An abnormal TREC test raises concern that the baby might have no or very low T cells.

If the results are abnormal, the provider will contact the family. If the results are normal, families are often not notified, but it is always important to confirm the newborn screening results with the baby’s primary healthcare provider.

An abnormal TREC result, also called positive, out-of-range, or high-risk, means that a baby needs more testing to see if they have a health condition affecting their T cells.

A normal TREC result, also called negative, in-range, or low-risk, means that it is unlikely that a baby has a health condition affecting their T cells.

The TREC screening results are either normal or abnormal. The number of TRECs detected indicates how many T cells a baby has. Since TRECs are small pieces of DNA, they can be detected reliably even on dried blood samples using a method called polymerase chain reaction (PCR). As T cells develop, they excise, or cut out, a small piece of DNA that forms a circle inside the developing cell-this is the TREC. TRECs are created when a type of white blood cell called a T cell matures in the thymus. To screen for SCID, the public health laboratory measures the number of T cell receptor excision circles (TRECs) in the baby’s blood. How does the screening test for SCID work?īeginning in December 2018, after 10 years of advocacy work by IDF, every state in the U.S., as well as Washington, D.C., Puerto Rico, Guam, and the Navajo Nation, now screens every newborn for SCID as part of the baby’s blood screening. Through the Recommended Uniform Screening Panel (RUSP), the Secretary of the Department of Health and Human Services (HHS) recommends states test for 37 core conditions and 26 secondary conditions.

In the United States, all states require newborn screening, but not every state screens for the same conditions.Almost 1 in 300 babies has a condition that can be detected through newborn screening.Nearly 4 million babies born in the U.S.Newborn screening can change a baby’s life by helping health professionals make a diagnosis and begin treatment before serious problems develop. For babies born with these serious, but treatable conditions, newborn screening allows them to receive a diagnosis and treatment as early as possible. Over 60 different conditions, including some PIs that affect white bood cells called T cells, can be detected through newborn screening. Many babies born with these conditions do not show any signs at birth, appear healthy, and have no family history of the condition. While originally intended to screen infants for common conditions, newborn screening tests are also performed for rare conditions that result in significant disease or carry a high risk of death early in life. It is a state-based public health service that ensures all babies are screened for certain conditions that can cause serious health problems. Newborn screening is an important part of a baby’s care.

What is scid deficicency